t(11;14) and t(4;14) translocations correlated with mature lymphoplasmacytoid and immature morphology, respectively, in multiple myeloma
โ Scribed by Garand, R; Avet-Loiseau, H; Accard, F; Moreau, P; Harousseau, J L; Bataille, R
- Book ID
- 110055621
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 139 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0887-6924
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## Abstract We describe the characterization of the genomic DNA breakpoints of two multiple myeloma (MM) patients with t(11;14). __IGH__ translocation events are present in many MM tumors, and it is proposed that they occur early in the pathogenesis, based on the assumption that the translocations
## Abstract Multiple myeloma (MM) is a malignancy of the plasma cells (PCs) characterized by a wide variety of genetic and chromosomal abnormalities. In recent years, major attention was drawn to the significance of chromosomal aberrations involving chromosome arm 13q and the __IGH__ region on chro