T-T cell interactions during in vitro cytotoxic T lymphocyte responses. III. Antigen-specific T helper cells release nonspecific mediator(s) able to help induction of H-2-restricted cytotoxic T lymphocyte responses across cell-impermeable membranes
✍ Scribed by Klaus Pfizenmaier; Rosemarie Delzeit; Martin Röllinghoff; Hermann Wagner
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 633 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Abstract
T helper cell induction and the specificity of T cell‐mediated help as generated during alloreactive and H‐2‐restricted, virus‐ or hapten‐specific cytotoxic T lymphocyte (CTL) responses have been compared. With the use of a double‐chamber culture system, it was possible to dissect and separately analyze the induction phase of T helper cells from the T helper cell effector function. The data obtained revealed that during alloreactive as well as H‐2‐restricted T cell responses, antigen‐specific T helper cells are induced. Upon specific restimulation of T helper cells, helper cell function is mediated across a cell‐impermeable membrane via soluble products in an apparently nonspecific and nonrestricted manner. The data suggest that similar rules govern T‐T cell interactions in alloreactive and H‐2‐restricted CTL responses.