T stage as prognostic factor in irradiated localized squamous cell carcinoma of the nasal vestibule

✍ Scribed by Eelco Kummer; Coen R. N. Rasch; Ronald B. Keus; I. Bing Tan; Alfons J. M. Balm

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 98 KB
• Volume: 24
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.10023

✦ Synopsis

Abstract

Background

To investigate the impact of T stage according to Wang on the prognosis of irradiated nasal vestibule carcinoma.

Patients and Methods

Treatment results of 47 patients were retrospectively analyzed. Treatment consisted of external beam radiotherapy (n = 26) or interstitial radiotherapy (n = 19) or a combination of both (n = 2) for a primary, localized, squamous cell carcinoma of the nasal vestibule. Mean follow‐up was 5 years and 7 months.

Results

T1/T2 tumors: Local control was achieved in 40 of 44 patients; surgical salvage was possible in 2 of 4 local failures. Five patients had recurrences in the neck, and four of them could be salvaged surgically. One patient had distant metastases develop. T3 tumors (n = 3): no T3 tumor could locally be cured by radiotherapy. One patient was salvaged surgically but died of regional and distant metastases. Disease‐specific survival is significantly correlated with T stage according to Wang (p = .0001). Most (85%) patients were smokers, and eight of them (20%) had a second primary tumor develop in the lungs.

Conclusions

The effect of radiotherapy is significantly correlated with T stage (p = .0001) and hence less successful in T3 lesions as primary treatment option. The high incidence of second primary tumors in the lung is indicative for a similar carcinogenic influence of smoking on the nasal vestibule. © 2002 Wiley Periodicals, Inc. Head Neck 24: 268–273, 2002; DOI 10.1002/hed.10023