𝔖 Bobbio Scriptorium
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T lymphocytes mediate immunologic control of C3 gene expression

✍ Scribed by Margaret B. Goldman; Mary Ann Knovich; John N. Goldman

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
909 KB
Volume
22
Category
Article
ISSN
0014-2980

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✦ Synopsis

T lymphocytes mediate immunologic control of C3 gene expression*

Immunologic control of C3 gene expression by tissue macrophages can be accomplished by treatment of spleen fragments with anti-C3 antibody. We now demonstrate that suppression of C3 requires participation of T lymphocytes of both the CD4+ and CD8+ phenotypes. Pretreatment of splenic tissue with anti-Thy-1.2 monoclonal antibody blocks the ability of the antLC3 antibody to induce C3 suppression. Reduction in either the CD4+ or CD8+ subpopulations of T lymphocytes also abrogates C3 suppression demonstrating that both T cell subsets are required in addition to the inducing antibody. Artificially elevating intracellular levels of CAMP with cholera toxin can partially substitute for the effects mediated by T cells in this reaction. Therefore, normal expression of the C3 gene can be suppressed by a regulatory network that requires the presence of a specific inducing antibody and Tlymphocytes of both the CD4+ and CD8+ subsets.This regulatory network has many similarities to regulatory networks that have been well documented in suppression of specific murine immunoglobulin allo types.

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