𝔖 Bobbio Scriptorium
✦   LIBER   ✦

T-Lymphocytes bearing the γδ T-cell receptor in cutaneous lesions of langerhans' cell histiocytosis

✍ Scribed by Alaibac, Mauro ;Chu, Anthony C.

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
611 KB
Volume
21
Category
Article
ISSN
0098-1532

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The aim of this study was to investigate the regional importance of γδ T cells in cutaneous lesions of Langerhans' cell histiocytosis. Six cases of Langerhans' cell histiocytosis were investigated by immunohistochemical techniques (alkaline phosphatase‐antialkaline phosphatase complex and indirect immunoperoxidase). Increase of γδ T cells was observed in 3 cases of Langerhans' cell histiocytosis. In these cases up to 30% of CD3^+^ cells stained with an anti‐TCR γδ monoclonal antibodies and in two of them γδ T cells showed a marked epidermotropism. In the specimens of the remaining three cases γδ T cells were found in an overall percentage of 5% of CD3^+^ cells, but in two cases a significant increase of epidermal γδ T cells was observed. The finding of numerous γδ T cells in Langerhans' cell histiocytosis is provocative and supports the suggestion of a functional relationship between γδ T cells and LCH cells. © 1993 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Lymphocytes bearing the γδ T cell recept
Lymphocytes bearing the γδ T cell receptor in acute Brucella melitensis infection
✍ Alberto Bertotto; Roberto Gerli; Fabrizio Spinozzi; Christopher Muscat; Francesc 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English

## Abstract A phenotypical analysis carried out by indirect immunofluorescence and two‐color cytofluorometry showed that the number of lymphocytes bearing the γδ T cell receptor (TcR) heterodimer was dramatically increased in the blood of six children with __Brucella melitensis__ infection. Most __