T lineage progenitors: the earliest steps en route to T lymphocytes

✍ Scribed by Li Wu

• Book ID: 104014462
• Publisher: Elsevier Science
• Year: 2006
• Tongue: English
• Weight: 186 KB
• Volume: 18
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/j.coi.2006.01.006

✦ Synopsis

T lineage progenitors: the earliest steps en route to T lymphocytes

Li Wu

T lymphocyte development in the thymus is a tightly regulated stepwise process. The identification and characterization of the earliest T lineage progenitors and their downstream progeny now enables the study of important cellular and molecular mechanisms that control and regulate T lineage commitment and differentiation. Significant progress has been made recently on the developmental relationships of the various cells with T cell progenitor activity identified in mouse bone marrow, blood and thymus, and on the molecular regulation of progenitor homing to the thymus. The essential role of Notch-1 signalling in intrathymic T lineage commitment and subsequent T cell development has been clearly documented.