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T helper cell unresponsiveness: Rapid induction in antigen-transgenic and reversion in non-transgenic mice

✍ Scribed by Martin F. Bachmann; Urs Hoffmann Rohrer; Ulrich Steinhoff; Kurt Bürki; Susan Skuntz; Heinz Arnheiter; Hans Hengartner; Rolf M. Zinkernagel


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
918 KB
Volume
24
Category
Article
ISSN
0014-2980

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Antigen-specific T cell tolerance can be induced by systemic injection of high-dose antigen. In particular, a single intravenous (i.v.) injection of influenza virus hemagglutinin peptide in HNT-TCR transgenic mice induces T cell tolerance through thymocyte apoptosis as well as anergy and deletion of