T Cells Use Rafts for Survival
β Scribed by Jennifer D. Stone; David M. Kranz
- Book ID
- 108152541
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 239 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1074-7613
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π SIMILAR VOLUMES
T cell survival in the periphery is an active process, depending on continuous TCR engagement by peptide-MHC complexes and/or response to environmental cytokines. Naive T cells require interactions with the MHC restricting element. The survival requirements of memory T cells are as yet insufficient
Raft microdomains have been shown to play a key role in T cell activation. We found that in human T lymphocytes the formation of functional rafts at the plasma membrane was induced by T cell priming. In resting T cells from peripheral blood Lck and the raft glycosphingolipid GM1 resided in intracell