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T cells in aging mice: genetic, developmental, and biochemical analyses

✍ Scribed by Richard A. Miller; Scott B. Berger; David T. Burke; Andrzej Galecki; Gonzalo G. Garcia; James M. Harper; Amir A. Sadighi Akha

Book ID: 110746596
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 366 KB
Volume: 205
Category: Article
ISSN: 0105-2896
DOI: 10.1111/j.0105-2896.2005.00254.x

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## Abstract Advancing age is associated with significant alterations in immune functions, including a decline in CD4 T cell function, in both mice and humans. In our previous report, we showed that CD4^+^CD25^–^ T cells in aged (24‐month‐old) mice, especially after __in vitro__ pre‐stimulation of t