T cell receptor Vβ gene utilization in myelin basic protein specific clones from CXJ1 recombinant inbred mice
✍ Scribed by Bernadette Kalman; Robert L. Knobler; Fred D. Lublin
- Book ID
- 119108494
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 360 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0165-5728
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Early studies of murine experimental autoimmune encephalomyelitis (EAE) induced with myelin basic protein (MBP) divide various mouse strains into either "susceptible" or "resistant" phenotypes. Resistance is defined as lack of encephalitogenic responses after active immunization or adoptive transfer
## Abstract We pursued a breeding strategy intended to generate disease‐resistant mice with exclusive expression of the H‐2^u^‐restricted myelin basic protein (MBP) 1‐11 peptide‐specific transgenic (Tg) T‐cell receptor (TCR) on the T‐cell‐deficient RAG1KO (H‐2^b^) background. Utilizing specific scr