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T-Cell Receptor (TCR)-Mediated Upregulation of BLT1 (LTB4 Receptor) Expression and Activation of Human T Cells by LTB4

✍ Scribed by Ahuja, A.; Dakhama, A.; Ohnishi, H.; Lucas, J.J.; Gelfand, E.W.

Book ID
119278166
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
48 KB
Volume
119
Category
Article
ISSN
1097-6825

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Background: Leukotriene B4 (LTB 4 ) has chemotactic properties for activated T cells expressing the high-affinity receptor BLT 1 . This study investigated whether the LTB 4 antagonist (CP-105,693), selective for BLT 1 receptor, could protect mice from colitis mediated by specific cytotoxic CD8 ΓΎ T l