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T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

✍ Scribed by Sauer, S.; Bruno, L.; Hertweck, A.; Finlay, D.; Leleu, M.; Spivakov, M.; Knight, Z. A.; Cobb, B. S.; Cantrell, D.; O'Connor, E.; Shokat, K. M.; Fisher, A. G.; Merkenschlager, M.

Book ID
118206270
Publisher
National Academy of Sciences
Year
2008
Tongue
English
Weight
47 KB
Volume
105
Category
Article
ISSN
0027-8424

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## Abstract Accumulating evidence suggest that trophic coupling among different cell types in the brain is required to maintain normal CNS function. Here we show that astrocytes secrete soluble factors that can be oligodendrocyte‐supportive. Oligodendrocyte precursor cells (OPCs) and astrocytes wer