T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man
β Scribed by Sakaguchi, Shimon; Benham, Helen; Cope, Andrew P; Thomas, Ranjeny
- Book ID
- 115469916
- Publisher
- Nature Publishing Group
- Year
- 2012
- Tongue
- English
- Weight
- 689 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0818-9641
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## Abstract ## Objective A wide spectrum of extraglandular manifestations may occur in patients with SjΓΆgren's syndrome (SS), but the mechanisms responsible for in vivo progression are still obscure. We undertook this study to evaluate the ageβrelated changes during the development of extraglandul
T cell receptor (TCR) peptide immunizations have been demonstrated to protect against experimental autoimmune diseases. These findings have led to clinical trials employing TCR peptides in multiple sclerosis and rheumatoid arthritis patients. Previously, we identified a strongly immunogenic region o