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T-cell receptor affinity in thymic development

✍ Scribed by Amy E. Moran; Kristin A. Hogquist

Book ID: 108782992
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 206 KB
Volume: 135
Category: Article
ISSN: 0019-2805
DOI: 10.1111/j.1365-2567.2011.03547.x

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Development is the process whereby a multipotent cell gives rise, through series of divisions, to progeny with successively restricted potentials. During T cell development, the process begins with a multipotent hematopoietic stem cell (HSC) in the bone marrow, moves to the thymus where early T cell