## Abstract Interleukin (IL‐) 27 is a member of IL‐12 cytokine family with Th1‐promoting and anti‐inflammatory effects. IL‐27 has been shown to facilitate tumor‐specific cytotoxic T lymphocyte (CTL) induction against various tumors. However, IL‐27 suppresses cytokine production of lymphocytes and a
✦ LIBER ✦
T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification
✍ Scribed by Anja Langenkamp; Giulia Casorati; Claudio Garavaglia; Paolo Dellabona; Antonio Lanzavecchia; Federica Sallusto
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 268 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0014-2980
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IL-12 activates TYK2 and Janus kinase (JAK)-2 to induce the phosphorylation of various signal transducers and activators of transcription (STAT) proteins. However, little is known regarding how these JAK exhibit the distinct biological effects of IL-12. Using two JAK inhibitors, tyrphostin A1 (A1) f