✦ LIBER ✦

T-cell leukemia with thymic involution

✍ Scribed by Samuel R. Newcom; Marshall E. Kadin

Book ID: 101325956
Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 458 KB
Volume: 43
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(197902)43:2<622::aid-cncr2820430232>3.0.co;2-q

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✦ Synopsis

The prognosis of acute lymphoblastic leukemia is affected adversely by T-cell markers on the malignant lymphoblasts. Direct involvement of the thymus has been assumed because of frequent mediastinal enlargement in these patients and the important role of the thymus in certain mouse leukemias. We report here an adult with T-cell leukemia and mediastinal enlargement who had physiologic involution of the thymus. The possible role of diphenylhydantoin in the pathogenesis of this disease is reviewed. The possible usefulness of Nu/Nu mouse xenografting for the study of this lethal disorder is discussed.

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