T cell interactions generated by synthetic peptides covalently linked to a carrier
β Scribed by Amanda Childerstone; Jay A. Haron; Thomas Lehner
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 851 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0014-2980
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Most antigens recognized by T cells require unfolding or partial degradation (processing) followed by association with Major Histocompatibility Complex (MHC) molecules. We examined the processing requirements for the presentation of antigen to two T cell hybridomas which recognize the alpha-helical
## Abstract The IiβKey fragment from the MHC class IIβassociated invariant chain (or Ii protein) has been shown to facilitate direct charging of MHC class II epitopes to the peptide binding groove. The purpose of the present study was to test the potential of a series of IiβKey/HERβ2__/neu__(776β79