Somatic Hypermutation in B Cells: An Opt
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Thomas B. Kepler; Alan S. Perelson
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Article
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1993
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Elsevier Science
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English
β 960 KB
The vertebrate immune system generates high-affinity antibodies to external antigens through a process of somatic hypermutation that takes place in germinal centers formed in the secondary lymphoid tissues. B cells proliferating in these germinal centers experience random mutations in the genes enco