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T Cell-Independent Somatic Hypermutation in Murine B Cells with an Immature Phenotype

✍ Scribed by Changchuin Mao; Liying Jiang; Milena Melo-Jorge; Maya Puthenveetil; Xiuli Zhang; Michael C. Carroll; Thereza Imanishi-Kari


Book ID
117723501
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
502 KB
Volume
20
Category
Article
ISSN
1074-7613

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The vertebrate immune system generates high-affinity antibodies to external antigens through a process of somatic hypermutation that takes place in germinal centers formed in the secondary lymphoid tissues. B cells proliferating in these germinal centers experience random mutations in the genes enco