T cell immunity in autoimmune hepatitis
โ Scribed by Yasunori Ichiki; Christopher A. Aoki; Christopher L. Bowlus; Shinji Shimoda; Hiromi Ishibashi; M. Eric Gershwin
- Book ID
- 113481695
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 149 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1568-9972
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๐ SIMILAR VOLUMES
Effector CD4 and CD8 T cell immune responses to cytochrome P450IID6 (CYP2D6), the autoantigen of autoimmune hepatitis type 2 (AIH-2), are permitted by a numerical and functional impairment of CD4(pos) CD25(high) regulatory T cells (T-regs). We aimed to investigate whether T-regs specific for CYP2D6
Autoimmune hepatitis type 2 (AIH-2) is a severe organ-specific disorder characterized by liver kidney microsomal antibody type 1 targeting cytochrome P4502D6 (CYP2D6). Growing evidence implicates the involvement of CD8 T cell immune responses in its pathogenesis. We investigated CYP2D6-specific CD8