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T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-γ

✍ Scribed by Yu, Qing; Sharma, Archna; Oh, Sun Young; Moon, Hyung-Geun; Hossain, M Zulfiquer; Salay, Theresa M; Leeds, Karen E; Du, Hansen; Wu, Beibei; Waterman, Marian L


Book ID
109920805
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
499 KB
Volume
10
Category
Article
ISSN
1529-2908

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## T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin42 and interferon-y and is inhibited by transforming growth factor+* Institut fur Immunologie, Maim It was observed in vitro and in vivo that both interferon (1FN)y and interleukin (1L)-12 can promote