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T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

✍ Scribed by Watford, Wendy T.; Wei, Lai; Xu, Lili; Fuss, Ivan; Strober, Warren; Andersson, John; Shevach, Ethan M.; Quezado, Martha; Bouladoux, Nicolas; Pesu, Marko


Book ID
109897627
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
735 KB
Volume
455
Category
Article
ISSN
0028-0836

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Interleukin-10 is crucial for maintenanc
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To asses the requirement of interleukin (IL)-10 for peripheral CD4 T cell tolerance, the IL-10 knockout (KO) was introduced into a T cell receptor-transgenic mouse model (TCR1) specific for SV40 T antigen (Tag). IL-10-deficient TCR1-transgenic mice failed to establish antigen-specific T cell toleran