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T Cell Epitopes of Insulin Defined in HLA-DR4 Transgenic Mice are Derived from Preproinsulin and Proinsulin

✍ Scribed by Mauro Congia, Salil Patel, Andrew P. Cope, Stefano De Virgiliis and Grete Sonderstrup


Book ID
123641184
Publisher
National Academy of Sciences
Year
1998
Tongue
English
Weight
860 KB
Volume
95
Category
Article
ISSN
0027-8424

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## Abstract ## Objective To establish a new animal model in DRB1\*0401 (DR4)–transgenic mice in which T cell tolerance to self type II collagen (CII) can be broken and allow for the development of autoimmune arthritis, to investigate the role of posttranslational modifications of the CII^259–273^