T-cell development: Thymus-settling progenitors: settled?
β Scribed by Izon, David J
- Book ID
- 109864771
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 82 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0818-9641
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π SIMILAR VOLUMES
The early events of T-cell generation, i.e. seeding of bone marrow-derived progenitor cells onto the thymic stroma, involve a small fraction (up to \(1 \%\) ) of thymus cells and are not presently observable. However, these events are crucial in determining the outcome of thymic colonization. In pre
Recent findings suggest that mature T cells in the thymus may regulate the growth and differentiation of immature thymocytes. Here we use mathematical modeling and computer simulations to identify the thymocyte subsets that might serve as targets for regulation, and the processes that might be affec