Mevalonate dependency of the early cell
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Marcela B. Ortiz; Mercedes Goin; Maria B. Gomez de Alzaga; Swen Hammarstrom; Lui
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Article
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1995
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John Wiley and Sons
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English
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Lovastatin (LOV), a hydroxy-methylglutaryl-coenzyme A (HMGCoA) reductase competitive inhibitor, blocks epidermal growth factor (EGF)or prostaglandin F , , (PGF,,)-induced mitogenesis in confluent resting Swiss 3T3 cells. This inhibition occurs even in the presence of insulin, which potentiates the a