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T-cell co-stimulation through B7RP-1 and ICOS

✍ Scribed by Yoshinaga, Steven K.; Whoriskey, John S.; Khare, Sanjay D.; Sarmiento, Ulla; Guo, Jane; Horan, Tom; Shih, Grace; Zhang, Ming; Coccia, Marco A.; Kohno, Tadahiko; Tafuri-Bladt, Anna; Brankow, David; Campbell, Pauline; Chang, David; Chiu, Laura; Dai, Tianang; Duncan, Gordon; Elliott, Gary S.; Hui, Ariela; McCabe, Susan M.; Scully, Sheila; Shahinian, Arda; Shaklee, Christine L.; Van, Gwyneth; Mak, Tak W.; Senaldi, Giorgio


Book ID
109819361
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
594 KB
Volume
402
Category
Article
ISSN
0028-0836

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87-I (CD80) provides co-stimulation for T-cell activation by interacting with CD28 or CTLA4. Here we demonstrate the expression of 87-I in freshly isolated and cultured lymphocytes from renal-cell carcinoma. In fresh preparations of lymphocytes infiltrating renal-cell-carcinoma tissue, B7-I mRNA cou