T-Cell clones with similar antigen specificity may be restricted by DR, MT (DC), or SB class II HLA molecules
✍ Scribed by Erik Qvigstad; Torolf Moen; Erik Thorsby
- Publisher
- Springer-Verlag
- Year
- 1984
- Tongue
- English
- Weight
- 353 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0093-7711
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✦ Synopsis
In man, at least three different class II HLA molecules have been detected: DR, DC, and SB. While the DR molecules appear to be analogous to the murine I-E molecules (Shackelford et al. 1982, Trowsdale et al. 1983), the DC molecules are composed of e and/~ chains structurally different from those of DR (Corte et al. 1981, Shackelford et al. 1981) and bear structural similarities to the I-A molecules. It is not settled whether the DC molecules are responsible for the serologically defined MT determinants (Arnot et al. 1984), or whether the DC and MT determinants are controlled by nonallelic genes (Sorrentino et al. 1983). The MT3 specificity may also represent a cross-reactive determinant present on products of both the DR and the DC loci (Goyert and Silver 1983). The secondary B-cell (SB) molecules were identified a few years ago by primed lymphocyte typing (PLT; Mawas et al. 1978, Shaw et al. 1980, Termijtelen et al. 1980), and they are encoded for by a locus centromeric to DR (Kavathas et al. 1981, Shaw et al. 1981). The SB system seems homologous to the murine I-E molecules (Hurley et al. 1982).
Human T helper/amplifier (T4) cells generally co-recognize antigenic epitopes together with restriction elements on class II HLA molecules in antigen-presenting cell (APC) membranes. We have previously reported that antigen-specific (i. e., specific for Chlamydia trachomatis) human T-lymphocyte clones (TLC) may be restricted by elements on DR or MT (DC) molecules (Qvigstad and Thorsby 1983). Quite recently, Eckels and co-workers (1983) reported that virus antigen-specific TLC may also use parts of the SB molecules as restriction elements. We describe here that TLC with specificity for antigens on C. trachomatis may also use parts of the SB molecules as restriction elements. Second, we demonstrate that TLC from a single donor, with similar antigen specificity, may be restricted by elements on DR, MT (DC) or SB HLA class II molecules.