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T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles

✍ Scribed by Soi Cheng Law, Shayna Street, Chien-Hsiung Alan Yu…

Book ID: 120706132
Publisher: BioMed Central
Year: 2012
Tongue: English
Weight: 792 KB
Volume: 14
Category: Article
ISSN: 1478-6354
DOI: 10.1186/ar3848

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## Abstract ## Objective The HLA shared epitope (SE) alleles are primarily a risk factor for the presence of antibodies to cyclic citrullinated peptide (anti‐CCP antibodies) rather than for the development of rheumatoid arthritis (RA). The SE alleles interact with the environmental risk factor tob