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Systems biology of neutrophil differentiation and immune response

✍ Scribed by Kim Theilgaard-Mönch; Bo T Porse; Niels Borregaard

Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
454 KB
Volume
18
Category
Article
ISSN
0952-7915

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✦ Synopsis

Systems biology has emerged as a new scientific field, which aims at investigating biological processes at the genomic and proteomic levels. Recent studies have unravelled aspects of neutrophil differentiation and immune responses at the systems level using high-throughput technologies. These studies have identified a plethora of novel effector proteins stored in the granules of neutrophils. In addition, these studies provide evidence that neutrophil differentiation and immune response are governed by a highly coordinated transcriptional programme that regulates cellular fate and function in a context-dependent manner.

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