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✦   LIBER   ✦
πŸ“

Systems Analysis of Human Multigene Disorders

✍ Scribed by Greg Gibson (auth.), Natalia Maltsev, Andrey Rzhetsky, T. Conrad Gilliam (eds.)

Publisher
Springer-Verlag New York
Year
2014
Tongue
English
Leaves
134
Series
Advances in Experimental Medicine and Biology 799
Edition
1
Category
Library
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✦ Synopsis

Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

✦ Table of Contents

Front Matter....Pages i-xiii
Wellness and Health Omics Linked to the Environment: The WHOLE Approach to Personalized Medicine....Pages 1-14
Characterizing Multi-omic Data in Systems Biology....Pages 15-38
High-Throughput Translational Medicine: Challenges and Solutions....Pages 39-67
Computational Approaches for Human Disease Gene Prediction and Ranking....Pages 69-84
A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization....Pages 85-117
Back Matter....Pages 119-122

✦ Subjects

Biomedicine general; Systems Biology; Human Genetics

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