𝔖 Bobbio Scriptorium
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Systemically transplanted bone marrow stromal cells contributing to bone tissue regeneration

✍ Scribed by S. Li; Q. Tu; J. Zhang; G. Stein; J. Lian; P.S. Yang; J. Chen

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
353 KB
Volume
215
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Bone marrow stromal cells (BMSCs) are a rich source of osteogenic progenitor cells. A fundamental question is whether systemically transplanted BMSCs participate in bone regeneration. Luciferase and GFP double‐labeled BMSCs were transplanted into irradiated mice. Five weeks after transplantation, artificial bone wounds were created in the mandibles and calvaria of the recipients. Animals were sacrificed at weeks 2, 4, and 6 after surgery and the expressions of luciferase and GFP were determined using Xenogen IVIS Imaging System, immunohistochemical staining and RT‐PCR. The results demonstrated that transplanted BMSCs can be detected in wound sites as early as 2 weeks and lasted the whole experimental period. Luciferase expression peaked at 2 weeks after surgery and decreased thereafter, exhibiting a similar expression pattern as that of BSP, while GFP expression was relatively stable during the experimental period. In conclusion, BMSCs can migrate to bone wound sites and participate in bone regeneration in orocraniofacial region. J. Cell. Physiol. 215: 204–209, 2008. © 2007 Wiley‐Liss, Inc.

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