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Systemic tumor necrosis factor α mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor α–transgenic mice

✍ Scribed by Ping Li; Edward M. Schwarz; Regis J. O'Keefe; Lin Ma; R. John Looney; Christopher T. Ritchlin; Brendan F. Boyce; Lianping Xing


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
224 KB
Volume
50
Category
Article
ISSN
0004-3591

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## Abstract ## Objective To investigate the safety of therapeutic tumor necrosis factor α (TNFα) blockade in patients with systemic lupus erythematosus (SLE), in whom this proinflammatory cytokine is significantly increased and may be involved in the disease pathogenesis. ## Methods In an open‐l