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Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients

✍ Scribed by Geja J Hageman; Ingrid Larik; Herman-Jan Pennings; Guido R.M.M Haenen; Emiel F.M Wouters; Aalt Bast

Book ID: 114275582
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 183 KB
Volume: 35
Category: Article
ISSN: 0891-5849
DOI: 10.1016/s0891-5849(03)00237-5

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## Abstract Continuously generated hydrogen peroxide (H~2~O~2~) inhibits typical apoptosis and instead initiates a caspase‐independent, apoptosis‐inducing factor (AIF)‐mediated pyknotic cell death. This may be related to H~2~O~2~‐mediated DNA damage and subsequent ATP depletion, although the exact