To investigate the role of nitric oxide in renal function and hemodynamics in cirrhotic patients with ascites, L- arginine (30 g in 300 mL of distilled water), a substrate for nitric oxide synthase, was infused into six cirrhotic patients with ascites, and the effects were compared with those of sal
Systemic hypotension and diuresis by l-arginine in cirrhotic patients with ascites: Role of nitric oxide
β Scribed by Kazuo Tajiri; Happei Miyakawa; Namiki Izumi; Fumiaki Marumo; Chifumi Sato
- Book ID
- 119155934
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 651 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0270-9139
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π SIMILAR VOLUMES
Nitric oxide is a vasodilator tonically secreted by endothelial cells that is involved in the regulation of arteriolar tone. This study, which includes two protocols, was performed to investigate whether nitric oxide plays a role in the pathogenesis of arterial hypotension in cirrhosis with ascites.
An increased release of nitric oxide (NO), a powerful vasodilating agent, has been proposed to play a role in the pathogenesis of vasodilation and hyperdynamic circulation associated with advanced cirrhosis. We evaluated NO synthase (NOS) activity in peripheral leukocytes of 12 cirrhotic patients an