Systemic hypotension and decreased pressor response in dogs with chronic bile duct ligation

✍ Scribed by Arieh Bomzon; Moshe Rosenberg; Devorah Gali; Ofer Binah; Dani Mordechovitz; Ori S. Better; Paul D. Greig; Professor Laurence M. Blendis

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 616 KB
• Volume: 6
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.1840060408

✦ Synopsis

Vascular instability as defined by systemic hypotension and unresponsiveness to endogenous or exogenous vasoactive substancea is a feature of both patients and experimental animals with obstructive jaundice. In this study, we have attempted to dissect the possible mechanisms for these abnormalities using both in uiuo and in uitro methods. In uiuo cumulative pressor responses (L) to intravenous and intraarterial infusions of norepinephrine and angiotensin 1 1 and to intravenous infusion of angiotensin I were studied pre-and postoperatively in chronic bile duct-ligated dogs and compared to sham-operated dogs. Preoperatively, the pressor responses to the cumulative infusion of six doses of vamactive substances in the pre-sham operated and prechronic bile duct-ligated dogs were not significantly different. Postoperatively, in the sham-operated dogs, there was no significant change in systemic blood pressure at 1 and 3 w e b , and only in isolated instances were significantly different pressor responses found compared to the preoperative result. In chronic bile duct-ligated dogs, the mean systemic blood pressure fell signifbantly from 117.2 f 3.1 to 107.2 2 3.0 m m Hg (p < 0.01) at 1 week and remained significantly lower at 3 weeks [109.7 f 2.6 mm Hg (p < 0.05)l. The R , , to intravenous, but not intraarterial norepinephrine, was significantly decreased. In contrast, the R , to both intravenous and intraarterial angiotensin 1 1 infusions were significantly depressed at both 1 and 3 weeks. Similarly, the response to intravenous angiotensin I was significantly depressed.

Cardiac output rose moderately in two sham-operated dogs from an average of 3.1 to 3.5 liters per min by 3 weeks associated with a decrease of 14.8% in peripheral