✦ LIBER ✦

Systemic autoimmune disease as a consequence of defective lymphocyte death

✍ Scribed by Thomas Hünig; Anneliese Schimpl

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 540 KB
Volume: 9
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(97)80185-9

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✦ Synopsis

Systemic autoimmune disease as a consequence of defective lymphocyte death Thomas HLinig* and Anneliese Schimpl

A major group of systemic autoimmune diseases is associated with abnormal lymphoproliferation, as a result of defects in the termination of lymphocyte activation and growth. Recent progress has been made in understanding the causes and consequences of these abnormalities. At the molecular level, the defects in CD95 and its ligand are only the most obvious masons for the breakdown of 'clonal contraction' which in fact requires the participation of multiple gene products, including the IL-2-1L-2-receptor system, to set up a functional apoptotic machinery.

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