✦ LIBER ✦

Systemic adoptive immunotherapy of a highly immunogenic murine lymphoma growing in the brain

✍ Scribed by L. Romani; R. Blanchi; P. Puccetti; M. C. Floretti

Book ID: 102863775
Publisher: John Wiley and Sons
Year: 1983
Tongue: French
Weight: 600 KB
Volume: 31
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910310413

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Systemic adoptive immunotherapy with specifically immune lymphocytes was successfully performed in immunodepressed mice challenged intracerebrally with L5178Y/DTIC lymphoma cells, a tumor subline rendered highly immunogenic through In vivo exposure to 5‐(3,3‐dimethyl‐1‐triazenyl)‐1H‐imidazole‐4‐carboxamide (DTIC)^1^. The systemic immunotherapy relied on the infusion of in vitro‐generated primary cytotoxic T‐lympho‐cytes (CTL), the anti‐tumor activity of which was evaluated by measuring tumor‐cell proliferation In the brain in terms of radiolabel uptake and by recording survival times of recipient leukemic mice. The protection afforded by CTL appeared to be specific and was largely conditioned by dose and time of CTL administration. The levels of protection correlated well with the in vitro killing of L5178Y/DTIC tumor cells.

📜 SIMILAR VOLUMES

Immunotherapy of a Murine T Cell Lymphom

Immunotherapy of a Murine T Cell Lymphoma Localized to the Brain

✍ Vithal K. Ghanta; Nancy S. Hiramoto; G.Y. Gillespie; Dorothy K. Gauthier; Raymon 📂 Article 📅 2000 🏛 Springer US 🌐 English ⚖ 89 KB

Augmentation by Tumor Necrosis Factor α

Augmentation by Tumor Necrosis Factor α of the Systemic Therapeutic Effect of Lymphokine-activated Killer Cells in Adoptive Immunotherapy of Murine Tumor

✍ Kato, Kazunori ;Tanabe, Toshifumi ;Agatsuma, Toshinori ;Suzuki, Shinya ;Nitanai, 📂 Article 📅 1991 🏛 Wiley (Blackwell Publishing) 🌐 English ⚖ 392 KB

Lack of correlation between DNA-methylat

Lack of correlation between DNA-methylating activity and appearance of the immunogenic phenotype in clones of a murine lymphoma treated with mutagens

✍ Patrizia Fuschiotti; Maria C. Fioretti; Luigina Romani; Paolo Puccetti 📂 Article 📅 1989 🏛 Springer-Verlag 🌐 English ⚖ 549 KB

The relationship between induction of novel immunogenicity by xenogenizing chemicals and DNA-methylating activity in murine tumors was investigated at the clonal level in L1210Ha cells treated with 5-azacytidine, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or 1-(p-chlorophenyl)-3,3-dimethyltriazene

Differential in situ expansion and gene

Differential in situ expansion and gene expression of CD4+ and CD8+ tumor-infiltrating lymphocytes following adoptive immunotherapy in a murine tumor model system

✍ Robert Evans; Theodore M. Duffy; Sonya J. Kamdar 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 584 KB

## Abstract In previous reports, we demonstrated that adoptively transferred T cells homed to the tumor site (among other sites) and that amplification of immune responses occurred __in situ__ leading to the generation of cytotoxic CD8^+^ tumor‐infiltrating lymphocytes (TIL) and macrophages. The pr

Second hit influences the interaction be

Second hit influences the interaction between tumor cells and the immune system in a murine model of Burkitt's lymphoma

✍ Christian Schuster; Anna Frenzel; Andrea Hölbl; Olivia Simma; Mathias Müller; An 📂 Article 📅 2008 🏛 BioMed Central 🌐 English ⚖ 64 KB

Murine Myak, a member of a family of yea

Murine Myak, a member of a family of yeast YAK1-related genes, is highly expressed in hormonally modulated epithelia in the reproductive system and in the embryonic central nervous system

✍ Enyuan Shang; Xiangyuan Wang; Jinghong Huang; Wataru Yoshida; Atsushi Kuroiwa; D 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 871 KB

We have cloned a mouse homologue (designated Myak) of the yeast protein kinase YAK1. The 1210 aa open reading frame contains a putative protein kinase domain, nuclear localization sequences and PEST sequences. Myak appears to be a member of a growing family of YAK1-related genes that include Drosoph