The oxidative decarboxylation of carboxylic acids by the chemical cytochrome P-450 model and rat liver microsomal systems was investigated. In the chemical system using meso-tetrakis(pentafluorophenyl)porphyrin iron chloride [Fe(TPFPP)Cl] with iodosylbenzene (PhIO), alpha-arylcarboxylic acids and al
Systematic study on the mechanism of aldehyde oxidation to carboxylic acid by cytochrome P450
✍ Scribed by Xiaojing Liu; Yong Wang; Keli Han
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 579 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1432-1327
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The oxidative metabolism of 4‐chloroacetanilide (4‐ClAA, 1) by cytochrome P450 has been studied theoretically using __ab‐initio__ energy and spin‐distribution calculations. A mechanism of oxidation for 4‐ClAA is proposed which is in accordance with recent views on the mechanism of metab
## Abstract Kinetic and mechanistic studies on the formation of an oxoiron(IV) porphyrin cation radical bearing a thiolate group as proximal ligand are reported. The **SR** complex, a functional enzyme mimic of P450, was oxidized in peroxo‐shunt reactions under different experimental conditions wit
## Abstract To determine the feasibility of using NMR to study the inactivation of cytochromes P‐450 by dichloroacetamide‐containing mechanism‐based inactivators, ^13^C, ^15^N‐enriched compounds were synthesized, modeling adducts between the nucleophilic side‐chains of cysteine, lysine, serine (thr
The catalytic system PdCI,(PPh,),-HCI is highly active and selective in the hydrogen transfer reaction from H,O-CO to PhCOCH,CHOHCOOH which yields the corresponding y-keto acid PhCOCH,CH,COOH, with concomitant evolution of C02. An increase of temperature, pressure of carbon monoxide and catalyst con