Systematic review to establish the safety profiles for direct and indirect inhibitors of p38 Mitogen-activated protein kinases for treatment of cancer

Activation of p38 mitogen-activated prot

Activation of p38 mitogen-activated protein kinase and mitochondrial Ca2+-mediated oxidative stress are essential for the enhanced expression of grp78 induced by the protein phosphatase inhibitors okadaic acid and calyculin A

✍ Kuang-Den Chen; Ming-Tsong Lai; Jun-Hung Cho; Liuh-Yow Chen; Yiu-Kay Lai 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 201 KB 👁 2 views

We have reported that treatment with okadaic acid, a potent protein phosphatase inhibitor, has the ability to enhance the synthesis of the 78-kDa glucose-regulated protein (GRP78). This article reports our investigation of another protein phosphatase inhibitor, calyculin A, demonstrating the signali