โ Scribed by Read, John
No coin nor oath required. For personal study only.
TIiis book, which i n tlic revisctl rtlition riiiis to 555 pagcs, forins n valuable niid comprclicnsivc rudc mmon for students and otlicrs \vho arc concerned with tlie practical operations of organic clicniistry. One citn say at once th:it it is a thoronglily sound and workinnnlikc prodiiction, tlic nse of \-liicli will do iiiiich to break down the distinction h t n e c n " Irctnrc-room " and " Iriborrrtory *' orpnic chcniistry, t o which Ilir iltithor~ refer i n thcir prcface.
ttiiiong the fcatiircs oI t l i ~ hook which cnll for pnrticulnr coinincndntioii, \vc inn? nicntion the ii(11iii~~iI)lt: sclcctioii nn,l :irraiigt.incwt of t hi1 rnnterinl, the constnnt rcfcrcncc to original pnpcrs, and tlic useful notes 011 siicli iiiiportant mnttcrs :is ciiutions, costing, nomcnclnturc, :ind the iisc of tlic Iihrriry. 'l'herc is n tinicly rcfcrciicc to first-nicl outfits 011 tlic first page, niitl Iicrc! it niriy be rrninrked that ninny IoLoratorics hnvc ab:inclonccl tlic use of lion-sterile ciirron oil in favour of sterilizctl liiirntl ressi ngs.
Tlic descriptions of apparatus and Inborntory operations shoiv obundnnt cvitlcncc of having bccii fraiiied by miters who are familiar witli nctual working conditions and with the supervision of laboratory workcrs. Nnturally, howcver, a work of this kind offers a broad target for detailed criticism nnd comment, anrl it may be of interest to remark upon a few special points.
The two quoted csarnplcs of optical rcsol~itioii (mantlclic acid and a-plicnylctliylaminc! pp. 407-110) are tlecidcdly difficult for a novice in this ficld of work. An :idmirnblc esariiplc of such a proccss is proritlcd by ~ll-isodiphenyll~ydro.uycthylaiinc, which is easily prcpnrcd from glycine (p. 439) and beiizaldchyde by Erlcnmcycr's method (Annalcn, 1809, 307, 120) and rcsolvcd with the aid of d-tartaric acid (I-basc) and d-camphor-10-siilplionic acid Id-basc) (J. Chem. Soc., 1920, 2309). Tlic raccmization of &tartaric acid, and t lie production of 1-tartaric acid from the resulting r:iccmic acid, might well bc included in this section.
In tlic preparation of d-camphor-10-sulplionic acid (p. 21 I), tlic sulphirric acid and acetic anhydride should be coolerl while being mised, tlie siilphoaation misturc nhould bc kept in a dry atmosphcrc throughout the cspcrimcnt, and thc product should be \vashcd with glacia2 acetic acid : thcsc important details are almost always omitted in descriptions of this process. A3-RIcnthcnc (p. 419) is prcpnred more readily from incnthol (J. Cliein. SOC., 1928,1492) thtrn from mcnthyl chlorido, and in both instances tho product is largely racemized ; if d-A3-mcnthene of liigli Rtcrcochcinical purity is required, tlie clcgant mcthod of Tschupcv (Bcr., 1899, 32, 3333) should be applicd to l-menthol.
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