Systematic investigation of the effect of lyophilizate collapse on pharmaceutically relevant proteins, part 2: Stability during storage at elevated temperatures

Systematic investigation of the effect o

Systematic investigation of the effect of lyophilizate collapse on pharmaceutically relevant proteins I: Stability after freeze-drying

✍ K. Schersch; O. Betz; P. Garidel; S. Muehlau; S. Bassarab; G. Winter 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 595 KB

The objective of this work was to investigate the effect of cake collapse during freeze-drying on the stability of protein lyophilizates containing a monoclonal IgG(1)-antibody or a second pharmaceutically relevant protein, referred to as PA01. In addition, L-lactic dehydrogenase was investigated be