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Systematic identification of T-cell activating epitopes on the human immunodeficiency virus type 1 envelope glycoprotein gp120 in primates immunized with synthetic peptides

✍ Scribed by Kristina Eriksson; Peter Horal; Bo Svennerholm; Stig Jeansson; Anders Vahlne; Jan Holmgen; Cecil Czerkinsky


Book ID
119151913
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
735 KB
Volume
11
Category
Article
ISSN
0264-410X

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The envelope glycoprotein (gpl20) of HIV-1 was labeled with fluorescein by using 6- [4,6-dichlorotriazinyl]aminofluorescein. The labeled glycoprotein was found to bind to CD4-positive CEM cells. Monoclonal antibody OKT4a but not OKT4 blocked this binding. Similar specific binding of fluorescein-labe