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System issues: Mutagenic response to benzene and Tris(2,3-dibromopropyl)-phosphate in the lambda lacl transgenic mouse mutation assay: A standardized approach to in vivo mutation analysis

✍ Scribed by G. S. Provost; J. C. Mirsalis; B. J. Rogers; J. M. Short

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 500 KB
Volume: 28
Category: Article
ISSN: 0893-6692
DOI: 10.1002/(sici)1098-2280(1996)28:4<342::aid-em7>3.0.co;2-d

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✦ Synopsis

The genotoxic response of benzene and his(2,3-dibromopropy1)-phosphate (TDBP) have been evaluated in several tissues using the standardized lambda/lacl (Big Blue@) transgenic mouse mutation assay. Separate groups of four to five male B6C3Fj transgenic lambda/lacl mice were given oral administrations of benzene or TDBP at varying concentrations. Tissues evaluated include lung, bone marrow, and spleen in benzene-treated animals, and liver, kidney, and stomach in TDBP-treated animals.