The feasibility of in vivo cellular imaging using a 1.5 T clinical magnet was studied in the mouse. Hybridoma cells were labeled with anionic gamma-Fe2O3 superparamagnetic iron oxide nanoparticles. These were internalized by the endocytose pathway. Both electron spin resonance and magnetophoresis as
System for prostate brachytherapy and biopsy in a standard 1.5 T MRI scanner
✍ Scribed by Robert C. Susil; Kevin Camphausen; Peter Choyke; Elliot R. McVeigh; Gary S. Gustafson; Holly Ning; Robert W. Miller; Ergin Atalar; C. Norman Coleman; Cynthia Ménard
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 449 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A technique for transperineal high‐dose‐rate (HDR) prostate brachytherapy and needle biopsy in a standard 1.5 T MRI scanner is demonstrated. In each of eight procedures (in four patients with intermediate to high risk localized prostate cancer), four MRI‐guided transperineal prostate biopsies were obtained followed by placement of 14–15 hollow transperineal catheters for HDR brachytherapy. Mean needle‐placement accuracy was 2.1 mm, 95% of needle‐placement errors were less than 4.0 mm, and the maximum needle‐placement error was 4.4 mm. In addition to guiding the placement of biopsy needles and brachytherapy catheters, MR images were also used for brachytherapy treatment planning and optimization. Because 1.5 T MR images are directly acquired during the interventional procedure, dependence on deformable registration is reduced and online image quality is maximized. Magn Reson Med 52:683–687, 2004. Published 2004 Wiley‐Liss, Inc.
📜 SIMILAR VOLUMES
## Abstract Clinicians currently use simple cut‐points, such as serum prostate‐specific antigen (PSA) ≥≥4 ng/ml, to decide whether to recommend further work‐up for prostate cancer (PCa). As an alternative strategy, we evaluated multivariable models giving probabilities of a PCa diagnosis based on P