✦ LIBER ✦
Synthèses Stéréosélectives des Acides 13 E et 13 Z Rétinoı̈ques via un Nouvel Intermédiaire β-Méthylènealdéhyde en C-15
✍ Scribed by Alain Valla; Zo Andriamialisoa; Virginie Prat; Alain Laurent; Michel Giraud; Roger Labia; Pierre Potier
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 146 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
The methylene-de-oxo-bisubstitution reaction between dimethyl isopropylidene malonate and the C-15 b-methylenealdehyde 1 which could serve as substitute for E b-ionylideneacetaldehyde 2, produces stereoselectively the E,E olefin. Hence, new stereoselective syntheses of 13 E and 13 Z retinoic acids were described.