Synthèse et propriétés amœbicides d'analogues de l'émétine. Analyse des composés nouveaux en 13C-RMN. I. (±) Alkyl-1-déséthyl-3-émétine à jonction B/C cis ou trans

✍ Scribed by André Buzas; Françoise Cossais; Jean-Pierre Finet; Jean-Pierre Jacquet; Gilbert Lavielle; Raymond Cavier; Nicole Platzer

• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: German
• Weight: 676 KB
• Volume: 60
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19770600703

✦ Synopsis

Synthesis and amoebicid properties of emetin analogs. Analysis of the new compounds by ^13^C‐NMR. B/C‐cis or trans‐fused (±) 1‐alkyl‐3‐desethyl‐emetin.

New 1‐alkyl‐3‐desethyl‐emetines were prepared for pharmacological purposes.

The usual emetine synthesis sequence applied to cis‐1‐alkylbenzo [a]quinolizidin‐2‐ones afforded new cis‐1‐alkyl‐3‐desethyl‐emetines.

The trans‐fused isomers were also prepared.

The relative configuration are determined by ^1^H‐ and ^13^C‐NMR. spectra.