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Synthèse et désamination enzymatique des C-hydroxyméthyl-3′- et C-méthyl-3′-β-D-xylofurannosyl-9-adénines

✍ Scribed by Jean M. J. Tronchet; Jeannine F. Tronchet

Publisher
John Wiley and Sons
Year
1979
Tongue
German
Weight
437 KB
Volume
62
Category
Article
ISSN
0018-019X

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✦ Synopsis

Synthesis and enzymatic deamination of 3′‐C‐hydroxymethyl‐ and 3′‐C‐methyl‐β‐D‐xylofuranosyl‐9‐adenines

The title compounds have been prepared by classical synthetic steps after having optimized the nature of the blocking groups. Both nucleosides were found to be substrates of adenosine aminohydrolase which proved that C(3′)‐branched‐chain sugar nucleosides can be deaminated when the branched‐chain is exo (trans relative to the base) if a suitably disposed hydroxy group is available on the endo side of the furanose ring.

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