Synthèse d'alcools acétyléniques par alkylation d'hydroxy-ω-alkynes-1

✍ Scribed by Jacques Flahaut; Philippe Miginiac

• Book ID: 102856253
• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: German
• Weight: 652 KB
• Volume: 61
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19780610635

✦ Synopsis

Synthesis of acetylenic alcohols by alkylation of ω‐hydroxy‐1‐alkynes

In liquid ammonia and with lithium amide, the alkylation of an ω‐hydroxyl‐alkyne proceeds with good yield with primary or secondary alcohols and with fair yield with tertiary alcohols. It is a very convenient way to prepare many substituted acetylenic alcohols.