✦ LIBER ✦

Synthetic study of tautomycin. I synthesis and regioselective enzymatic acetylation of a spiroketal diol related to the C516 fragment

✍ Scribed by Shinji Nagumo; Takayuki Arai; Hiroyuki Akita

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 222 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01118-0

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✦ Synopsis

Spiroketal diol I was pt~ ft~nm 5, which can be obtained by em~tio-selective enzymatic acetylation of meso diol 6, in 12 steps in 16.5% total yield and its regioselective protection was achieved by an enzymatic method to give 1 6 in high yield.