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Synthetic study of polyoxypeptin: stereoselective synthesis of the acyl side-chain segment

โœ Scribed by Yasuo Noguchi; Tatsuhiro Yamada; Hiromi Uchiro; Susumu Kobayashi

Book ID
104210834
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
142 KB
Volume
41
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The first synthesis of the acyl side-chain segment of polyoxypeptin, a potent inducer of apoptosis in human pancreatic carcinoma AsPC-1, was accomplished. The key feature of the present synthesis is the stereospecific palladium-catalyzed hydrogenolysis of (Z)-alkenyloxirane to anti-hydroxyalkenoate by an improved method.

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