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Synthetic study of aquayamycin. Part 2: Synthesis of the AB ring fragment

✍ Scribed by Hiroki Yamaguchi; Tadayoshi Konegawa; Mitsujiro Tanabe; Takeshi Nakamura; Takashi Matsumoto; Keisuke Suzuki

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 64 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01479-9

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✦ Synopsis

A highly oxygen-functionalized cyclohexenone 2, the AB ring fragment for the aquayamycin synthesis, was efficiently synthesized via stereoselective addition of allylzinc bromide to ketone 3a which, in turn, was available from the optically pure cyclohexane 1,2,3-triol derivative 5.

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